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Structural Insight into Tetrameric hTRPV1 from Homology Modeling, Molecular Docking, Molecular Dynamics Simulation, Virtual Screening, and Bioassay Validations

The transient receptor potential vanilloid type 1 (TRPV1) is a heat-activated cation channel protein, which contributes to inflammation, acute and persistent pain. Antagonists of human TRPV1 (hTRPV1) represent a novel therapeutic approach for the treatment of pain. Developing various antagonists of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Chem Inf Model
Prif Awduron: Feng, Zhiwei, Pearce, Larry V., Xu, Xiaomeng, Yang, Xiaole, Yang, Peng, Blumberg, Peter M., Xie, Xiang-Qun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508124/
https://ncbi.nlm.nih.gov/pubmed/25642729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci5007189
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