RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response

BACKGROUND: The heat shock response (HSR) is an ancient and highly conserved program of stress-induced gene expression, aimed at reestablishing protein homeostasis to preserve cellular fitness. Cells that fail to activate or maintain this protective response are hypersensitive to proteotoxic stress....

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Pubblicato in:PLoS One
Autori principali: Meijering, Roelien A. M., Wiersma, Marit, van Marion, Denise M. S., Zhang, Deli, Hoogstra-Berends, Femke, Dijkhuis, Anne-Jan, Schmidt, Martina, Wieland, Thomas, Kampinga, Harm H., Henning, Robert H., Brundel, Bianca J. J. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508109/
https://ncbi.nlm.nih.gov/pubmed/26193369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133553
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