Enhanced GABAergic Inputs Contribute to Functional Alterations of Cholinergic Interneurons in the R6/2 Mouse Model of Huntington’s Disease1,2,3

In Huntington’s disease (HD), a hereditary neurodegenerative disorder, striatal medium-sized spiny neurons undergo degenerative changes. In contrast, large cholinergic interneurons (LCIs) are relatively spared. However, their ability to release acetylcholine (ACh) is impaired. The present experiment...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Holley, Sandra M., Joshi, Prasad R., Parievsky, Anna, Galvan, Laurie, Chen, Jane Y., Fisher, Yvette E., Huynh, My N., Cepeda, Carlos, Levine, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
Assuntos:
New Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507822/
https://ncbi.nlm.nih.gov/pubmed/26203463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0008-14.2015
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