Therapy-induced tumour secretomes promote resistance and tumour progression

Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2). Here we show that targeted therapy with BRAF, ALK, or EGFR kinase inhibitors induces a complex network of secreted signals in drug-stressed melanoma and lung adenocarcinoma cells....

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Obenauf, Anna C., Zou, Yilong, Ji, Andrew L., Vanharanta, Sakari, Shu, Weiping, Shi, Hubing, Kong, Xiangju, Bosenberg, Marcus C., Wiesner, Thomas, Rosen, Neal, Lo, Roger S., Massagué, Joan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507807/
https://ncbi.nlm.nih.gov/pubmed/25807485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14336
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