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Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes

Transfer of GABARAP thioester from the E1 ATG7 to the E2 ATG3 requires the interaction between the N-terminal domain of ATG7 and the flexible region (FR) of ATG3. This interaction has been visualized in the yeast Atg7-Atg3 complex crystal structure, but remains to be defined in higher eukaryotes. He...

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Publicado en:Biochem Biophys Res Commun
Autores principales: Ohashi, Kazuto, Otomo, Takanori
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507496/
https://ncbi.nlm.nih.gov/pubmed/26043688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.05.107
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