Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex

Acetylation is correlated with chromatin decondensation and transcriptional activation, but its regulation by histone deacetylase (HDAC)-bearing corepressor complexes is poorly understood. Here, we describe the mechanism of assembly of the mammalian Sin3L/Rpd3L complex facilitated by Sds3, a conserv...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Clark, Michael D., Marcum, Ryan, Graveline, Richard, Chan, Clarence W., Xie, Tao, Chen, Zhonglei, Ding, Yujia, Zhang, Yongbo, Mondragón, Alfonso, David, Gregory, Radhakrishnan, Ishwar
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507224/
https://ncbi.nlm.nih.gov/pubmed/26124119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504021112
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