Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels

BACKGROUND AND PURPOSE: The cation channel transient receptor potential canonical (TRPC) 6 has been associated with several pathologies including focal segmental glomerulosclerosis, pulmonary hypertension and ischaemia reperfusion-induced lung oedema. We set out to discover novel inhibitors of TRPC6...

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Bibliografski detalji
Izdano u:Br J Pharmacol
Glavni autori: Maier, T, Follmann, M, Hessler, G, Kleemann, H-W, Hachtel, S, Fuchs, B, Weissmann, N, Linz, W, Schmidt, T, Löhn, M, Schroeter, K, Wang, L, Rütten, H, Strübing, C
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2015
Teme:
Research Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507166/
https://ncbi.nlm.nih.gov/pubmed/25847402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13151
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