Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels

BACKGROUND AND PURPOSE: The cation channel transient receptor potential canonical (TRPC) 6 has been associated with several pathologies including focal segmental glomerulosclerosis, pulmonary hypertension and ischaemia reperfusion-induced lung oedema. We set out to discover novel inhibitors of TRPC6...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Maier, T, Follmann, M, Hessler, G, Kleemann, H-W, Hachtel, S, Fuchs, B, Weissmann, N, Linz, W, Schmidt, T, Löhn, M, Schroeter, K, Wang, L, Rütten, H, Strübing, C
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2015
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507166/
https://ncbi.nlm.nih.gov/pubmed/25847402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13151
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