Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels

BACKGROUND AND PURPOSE: The cation channel transient receptor potential canonical (TRPC) 6 has been associated with several pathologies including focal segmental glomerulosclerosis, pulmonary hypertension and ischaemia reperfusion-induced lung oedema. We set out to discover novel inhibitors of TRPC6...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Maier, T, Follmann, M, Hessler, G, Kleemann, H-W, Hachtel, S, Fuchs, B, Weissmann, N, Linz, W, Schmidt, T, Löhn, M, Schroeter, K, Wang, L, Rütten, H, Strübing, C
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507166/
https://ncbi.nlm.nih.gov/pubmed/25847402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13151
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados