Synergistic enhancement of parasiticidal activity of amphotericin B using copaiba oil in nanoemulsified carrier for oral delivery: an approach for non-toxic chemotherapy

BACKGROUND AND PURPOSE: The aim of this study was to devise a nanoemulsified carrier system (CopNEC) to improve the oral delivery of amphotericin B (AmB) by increasing its oral bioavailability and synergistically enhance its antileishmanial activity with copaiba oil (Cop). EXPERIMENTAL APPROACH: The...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Gupta, Pramod K, Jaiswal, Anil K, Asthana, Shalini, Teja B, Venkatesh, Shukla, Prashant, Shukla, Minakshi, Sagar, Neeti, Dube, Anuradha, Rath, Srikanta K, Mishra, Prabhat R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507162/
https://ncbi.nlm.nih.gov/pubmed/25825339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13149
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