Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion

Mechanisms of gender-specific synaptic plasticity in the striatum, a brain region that controls motor, cognitive and psychiatric functions, remain unclear. Here we report that Rhes, a GTPase enriched in medium spiny neurons (MSNs) of striatum, alters the striatal cAMP/PKA signaling cascade in a gend...

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Publicado en:Sci Rep
Autores principales: Ghiglieri, Veronica, Napolitano, Francesco, Pelosi, Barbara, Schepisi, Chiara, Migliarini, Sara, Di Maio, Anna, Pendolino, Valentina, Mancini, Maria, Sciamanna, Giuseppe, Vitucci, Daniela, Maddaloni, Giacomo, Giampà, Carmela, Errico, Francesco, Nisticò, Robert, Pasqualetti, Massimo, Picconi, Barbara, Usiello, Alessandro
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507147/
https://ncbi.nlm.nih.gov/pubmed/26190541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10933
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