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Interferon Lambda Upregulates IDO1 Expression in Respiratory Epithelial Cells After Influenza Virus Infection

Influenza infection causes an increase in indoleamine 2, 3-dioxygenase (IDO) activity in the lung parenchyma. IDO catabolizes tryptophan into kynurenine, leading to immune dampening. Multiple cell types express IDO, and while IFN-γ upregulates IDO in dendritic cells and macrophages, it is unclear ho...

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書誌詳細
出版年:J Interferon Cytokine Res
主要な著者: Fox, Julie M., Crabtree, Jackelyn M., Sage, Leo K., Tompkins, S. Mark, Tripp, Ralph A.
フォーマット: Artigo
言語:Inglês
出版事項: Mary Ann Liebert, Inc. 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507134/
https://ncbi.nlm.nih.gov/pubmed/25756191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2014.0052
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