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Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection

Influenza infection induces an increase in the level of indoleamine 2,3-dioxygenase (IDO) activity in the lung parenchyma. IDO is the first and rate-limiting step in the kynurenine pathway where tryptophan is reduced to kynurenine and other metabolites. The depletion of tryptophan, and production of...

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Detalhes bibliográficos
Main Authors: Fox, Julie M., Sage, Leo K., Huang, Lei, Barber, James, Klonowski, Kimberly D., Mellor, Andrew L., Tompkins, S. Mark, Tripp, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709631/
https://ncbi.nlm.nih.gov/pubmed/23580425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.053124-0
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