Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

Dominant mutations in five tRNA synthetases cause Charcot–Marie–Tooth (CMT) neuropathy, suggesting that altered aminoacylation function underlies the disease. However, previous studies showed that loss of aminoacylation activity is not required to cause CMT. Here we present a Drosophila model for CM...

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Publicado no:Nat Commun
Main Authors: Niehues, Sven, Bussmann, Julia, Steffes, Georg, Erdmann, Ines, Köhrer, Caroline, Sun, Litao, Wagner, Marina, Schäfer, Kerstin, Wang, Guangxia, Koerdt, Sophia N., Stum, Morgane, RajBhandary, Uttam L., Thomas, Ulrich, Aberle, Hermann, Burgess, Robert W., Yang, Xiang-Lei, Dieterich, Daniela, Storkebaum, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506996/
https://ncbi.nlm.nih.gov/pubmed/26138142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8520
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