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Lack of Major Histocompatibility Complex Class I Upregulation and Restrictive Infection by JC Virus Hampers Detection of Neurons by T-Lymphocytes in the Central Nervous System

The human polyomavirus JC (JCV) infects glial cells in immunosuppressed individuals leading to progressive multifocal leukoencephalopathy (PML). JCV can also infect neurons in patients with JCV granule cell neuronopathy and JCV encephalopathy. CD8-positive T-cells play a crucial role in viral contai...

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Bibliografiske detaljer
Udgivet i:J Neuropathol Exp Neurol
Main Authors: Wüthrich, Christian, Batson, Stephanie, Koralnik, Igor J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506730/
https://ncbi.nlm.nih.gov/pubmed/26115192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0000000000000218
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