Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome analyses to unravel the genetic/epigenetic basis of RMS. On the basis of methylation patterns, RMS is clustered into fou...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Seki, Masafumi, Nishimura, Riki, Yoshida, Kenichi, Shimamura, Teppei, Shiraishi, Yuichi, Sato, Yusuke, Kato, Motohiro, Chiba, Kenichi, Tanaka, Hiroko, Hoshino, Noriko, Nagae, Genta, Shiozawa, Yusuke, Okuno, Yusuke, Hosoi, Hajime, Tanaka, Yukichi, Okita, Hajime, Miyachi, Mitsuru, Souzaki, Ryota, Taguchi, Tomoaki, Koh, Katsuyoshi, Hanada, Ryoji, Kato, Keisuke, Nomura, Yuko, Akiyama, Masaharu, Oka, Akira, Igarashi, Takashi, Miyano, Satoru, Aburatani, Hiroyuki, Hayashi, Yasuhide, Ogawa, Seishi, Takita, Junko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506514/
https://ncbi.nlm.nih.gov/pubmed/26138366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8557
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