Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets

Although hepatoblastoma is the most common pediatric liver cancer, its genetic heterogeneity and therapeutic targets are not well elucidated. Therefore, we conducted a multiomics analysis, including mutatome, DNA methylome, and transcriptome analyses, of 59 hepatoblastoma samples. Based on DNA methy...

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Detalhes bibliográficos
Publicado no:NPJ Precis Oncol
Main Authors: Sekiguchi, Masahiro, Seki, Masafumi, Kawai, Tomoko, Yoshida, Kenichi, Yoshida, Misa, Isobe, Tomoya, Hoshino, Noriko, Shirai, Ryota, Tanaka, Mio, Souzaki, Ryota, Watanabe, Kentaro, Arakawa, Yuki, Nannya, Yasuhito, Suzuki, Hiromichi, Fujii, Yoichi, Kataoka, Keisuke, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Shimamura, Teppei, Sato, Yusuke, Sato-Otsubo, Aiko, Kimura, Shunsuke, Kubota, Yasuo, Hiwatari, Mitsuteru, Koh, Katsuyoshi, Hayashi, Yasuhide, Kanamori, Yutaka, Kasahara, Mureo, Kohashi, Kenichi, Kato, Motohiro, Yoshioka, Takako, Matsumoto, Kimikazu, Oka, Akira, Taguchi, Tomoaki, Sanada, Masashi, Tanaka, Yukichi, Miyano, Satoru, Hata, Kenichiro, Ogawa, Seishi, Takita, Junko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341754/
https://ncbi.nlm.nih.gov/pubmed/32656360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-020-0125-y
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