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Improving survival by exploiting tumor dependence on stabilized mutant p53 for treatment
Missense mutations in p53 generate aberrant proteins with abrogated tumor suppressor functions that can also acquire oncogenic gain-of-functions (GOF) that promote malignant progression, invasion, metastasis and chemoresistance(1–5). Mutant p53 (mutp53) proteins undergo massive constitutive stabiliz...
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| Publié dans: | Nature |
|---|---|
| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506213/ https://ncbi.nlm.nih.gov/pubmed/26009011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14430 |
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