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Interleukin-1β protects astrocytes against oxidant-induced injury via an NFκB-dependent upregulation of glutathione synthesis
Astrocytes produce and export the antioxidant glutathione (GSH). Previously, we found that interleukin-1β (IL-1β) enhanced the expression of astrocyte system x(c)(−), the transporter that delivers the rate-limiting substrate for GSH synthesis —cyst(e)ine. Herein, we demonstrate directly that IL-1β m...
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| Publicado no: | Glia |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506211/ https://ncbi.nlm.nih.gov/pubmed/25880604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22828 |
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