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Interleukin-1β protects astrocytes against oxidant-induced injury via an NFκB-dependent upregulation of glutathione synthesis

Astrocytes produce and export the antioxidant glutathione (GSH). Previously, we found that interleukin-1β (IL-1β) enhanced the expression of astrocyte system x(c)(−), the transporter that delivers the rate-limiting substrate for GSH synthesis —cyst(e)ine. Herein, we demonstrate directly that IL-1β m...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Glia
Prif Awduron: He, Yan, Jackman, Nicole A., L.Thorn, Trista, Vought, Valarie E., Hewett, Sandra J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506211/
https://ncbi.nlm.nih.gov/pubmed/25880604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22828
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