Folded or Not? Tracking Bet v 1 Conformation in Recombinant Allergen Preparations

BACKGROUND: Recombinant Bet v 1a (rBet v 1a) has been used in allergy research for more than three decades, including clinical application of so-called hypoallergens. Quantitative IgE binding to rBet v 1a depends on its native protein conformation, which might be compromised upon heterologous expres...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Husslik, Felix, Hanschmann, Kay-Martin, Krämer, Ariane, Seutter von Loetzen, Christian, Schweimer, Kristian, Bellinghausen, Iris, Treudler, Regina, Simon, Jan C., Vogel, Lothar, Völker, Elke, Randow, Stefanie, Reuter, Andreas, Rösch, Paul, Vieths, Stefan, Holzhauser, Thomas, Schiller, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506129/
https://ncbi.nlm.nih.gov/pubmed/26186356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132956
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