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Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4(+) T Lymphocytes
Vpr is a conserved primate lentiviral protein that promotes infection of T lymphocytes in vivo by an unknown mechanism. Here we demonstrate that Vpr and its cellular co-factor, DCAF1, are necessary for efficient cell-to-cell spread of HIV-1 from macrophages to CD4(+) T lymphocytes when there is inad...
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| Publicat a: | PLoS Pathog |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506080/ https://ncbi.nlm.nih.gov/pubmed/26186441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005054 |
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