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Activation of the double-stranded RNA (dsRNA)-activated human protein kinase in vivo in the absence of its dsRNA binding domain.

The interferon-induced, dsRNA-activated human protein kinase (PKR) exerts antiviral and antiproliferative effects through inhibition of protein synthesis. Studies of structure-function relationships in PKR have shown that two dsRNA binding motifs are important for its autophosphorylation and activat...

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Bibliografski detalji
Glavni autori: Lee, S B, Green, S R, Mathews, M B, Esteban, M
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC45059/
https://ncbi.nlm.nih.gov/pubmed/7937992
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