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Genital tenofovir concentrations correlate with protection against HIV infection in the CAPRISA 004 trial: Importance of adherence for microbicide effectiveness

OBJECTIVE: The CAPRISA 004 trial showed that coitally-dosed tenofovir 1% gel reduced HIV acquisition by 39% overall and 54% when used consistently. The objective of this analysis was to ascertain its pharmacokinetic-pharmacodynamic relationship to protection against HIV acquisition. DESIGN: Genital...

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Podrobná bibliografie
Vydáno v:J Acquir Immune Defic Syndr
Hlavní autoři: Kashuba, Angela DM, Gengiah, Tanuja N, Werner, Lise, Yang, Kuo-Hsiung, White, Nicole R, Karim, Quarraisha Abdool, Abdool Karim, Salim S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505741/
https://ncbi.nlm.nih.gov/pubmed/26181703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000607
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