Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection

More than 10% of the world’s population is chronically infected with HIV, HCV or HBV, which cause severe disease and death. These viruses persist in part because continuous antigenic stimulation causes deterioration of virus-specific cytotoxic T lymphocyte (CTL) function and survival. Additionally,...

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Publicat a:Nat Med
Autors principals: Chen, Jonathan H., Perry, Curtis J., Tsui, Yao-Chen, Staron, Matthew M., Parish, Ian A., Dominguez, Claudia X., Rosenberg, Daniel W., Kaech, Susan M.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505619/
https://ncbi.nlm.nih.gov/pubmed/25799228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3831
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