Expanding Regulatory T Cells Alleviates Chikungunya Virus-Induced Pathology in Mice

Chikungunya virus (CHIKV) infection is a reemerging pandemic human arboviral disease. CD4(+) T cells were previously shown to contribute to joint inflammation in the course of CHIKV infection in mice. The JES6-1 anti-IL-2 antibody selectively expands mouse regulatory T cells (Tregs) by forming a com...

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Udgivet i:J Virol
Main Authors: Lee, Wendy W. L., Teo, Teck-Hui, Her, Zhisheng, Lum, Fok-Moon, Kam, Yiu-Wing, Haase, Doreen, Rénia, Laurent, Rötzschke, Olaf, Ng, Lisa F. P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505607/
https://ncbi.nlm.nih.gov/pubmed/25995249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00998-15
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