Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA

3′ repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the antiviral response. In this work, we show that TREX1 is also a RNA exonuclease. Purified TREX1 displays robust exoribonuclease activity that degrades single-stranded, but not double-stranded, RNA. TRE...

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Vydáno v:J Biol Chem
Hlavní autoři: Yuan, Fenghua, Dutta, Tanmay, Wang, Ling, Song, Lei, Gu, Liya, Qian, Liangyue, Benitez, Anaid, Ning, Shunbin, Malhotra, Arun, Deutscher, Murray P., Zhang, Yanbin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505584/
https://ncbi.nlm.nih.gov/pubmed/25855793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.653915
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