Methylation of Gata3 Protein at Arg-261 Regulates Transactivation of the Il5 Gene in T Helper 2 Cells

Gata3 acts as a master regulator for T helper 2 (Th2) cell differentiation by inducing chromatin remodeling of the Th2 cytokine loci, accelerating Th2 cell proliferation, and repressing Th1 cell differentiation. Gata3 also directly transactivates the interleukin-5 (Il5) gene via additional mechanism...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Hosokawa, Hiroyuki, Kato, Miki, Tohyama, Hiroyuki, Tamaki, Yuuki, Endo, Yusuke, Kimura, Motoko Y., Tumes, Damon John, Motohashi, Shinichiro, Matsumoto, Masaki, Nakayama, Keiichi I., Tanaka, Tomoaki, Nakayama, Toshinori
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505565/
https://ncbi.nlm.nih.gov/pubmed/25861992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.621524
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