تحميل...
Alteration of Electrostatic Surface Potential Enhances Affinity and Tumor Killing Properties of Anti-ganglioside GD2 Monoclonal Antibody hu3F8
Ganglioside GD2 is highly expressed on neuroectodermal tumors and an attractive therapeutic target for antibodies that have already shown some clinical efficacy. To further improve the current antibodies, which have modest affinity, we sought to improve affinity by using a combined method of random...
محفوظ في:
| الحاوية / القاعدة: | J Biol Chem |
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| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
American Society for Biochemistry and Molecular Biology
2015
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505556/ https://ncbi.nlm.nih.gov/pubmed/25851904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.650903 |
| الوسوم: |
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