Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

Using an unbiased systems genetics approach, we previously predicted a role for CHAC1 in the endoplasmic reticulum stress pathway, linked functionally to activating transcription factor 4 (ATF4) following treatment with oxidized phospholipids, a model for atherosclerosis. Mouse and yeast CHAC1 homol...

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Vydáno v:J Biol Chem
Hlavní autoři: Crawford, Rebecca R., Prescott, Eugenia T., Sylvester, Charity F., Higdon, Ashlee N., Shan, Jixiu, Kilberg, Michael S., Mungrue, Imran N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505494/
https://ncbi.nlm.nih.gov/pubmed/25931127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.635144
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