Casein Kinase 2 (CK2)-mediated Phosphorylation of Hsp90β as a Novel Mechanism of Rifampin-induced MDR1 Expression

The P-glycoprotein (P-gp) encoded by the MDR1 gene is a drug-exporting transporter located in the cellular membrane. P-gp induction is regarded as one of the main mechanisms underlying drug-induced resistance. Although there is great interest in the regulation of P-gp expression, little is known abo...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Kim, So Won, Hasanuzzaman, Md., Cho, Munju, Heo, Ye Rang, Ryu, Min-Jung, Ha, Na-Young, Park, Hyun June, Park, Hyung-Yeon, Shin, Jae-Gook
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505446/
https://ncbi.nlm.nih.gov/pubmed/25995454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624106
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