Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I

Collagen prolyl 4-hydroxylases (C-P4H-I, C-P4H-II, and C-P4H-III) catalyze formation of 4-hydroxyproline residues required to form triple-helical collagen molecules. Vertebrate C-P4Hs are α(2)β(2) tetramers differing in their catalytic α subunits. C-P4H-I is the major isoenzyme in most cells, and in...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Aro, Ellinoora, Salo, Antti M., Khatri, Richa, Finnilä, Mikko, Miinalainen, Ilkka, Sormunen, Raija, Pakkanen, Outi, Holster, Tiina, Soininen, Raija, Prein, Carina, Clausen-Schaumann, Hauke, Aszódi, Attila, Tuukkanen, Juha, Kivirikko, Kari I., Schipani, Ernestina, Myllyharju, Johanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505441/
https://ncbi.nlm.nih.gov/pubmed/26001784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662635
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