The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway

Parathyroid hormone (PTH) induces osteoclast formation and activity by increasing the ratio of RANKL/OPG in osteoblasts. The proteasome inhibitor carfilzomib (CFZ) has been used as an effective therapy for multiple myeloma via the inhibition of pathologic bone destruction. However, the effect of com...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Yang, Yanmei, Blair, Harry C., Shapiro, Irving M., Wang, Bin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505437/
https://ncbi.nlm.nih.gov/pubmed/25979341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663963
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