SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell

SET7/9 is an enzyme that methylates histone 3 at lysine 4 (H3K4) to maintain euchromatin architecture. Although SET7/9 is enriched in islets and contributes to the transactivation of β cell-specific genes, including Ins1 and Slc2a, SET7/9 has also been reported to bind the p65 subunit of nuclear fac...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Fujimaki, Kyoko, Ogihara, Takeshi, Morris, David L., Oda, Hisanobu, Iida, Hitoshi, Fujitani, Yoshio, Mirmira, Raghavendra G., Evans-Molina, Carmella, Watada, Hirotaka
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505414/
https://ncbi.nlm.nih.gov/pubmed/25995453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.661777
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