The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence

Mycobacterium tuberculosis must sense and adapt to host environmental cues to establish and maintain an infection. The two-component regulatory system PhoPR plays a central role in sensing and responding to acidic pH within the macrophage and is required for M. tuberculosis intracellular replication...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Johnson, Benjamin K., Colvin, Christopher J., Needle, David B., Mba Medie, Felix, Champion, Patricia A. DiGiuseppe, Abramovitch, Robert B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505220/
https://ncbi.nlm.nih.gov/pubmed/25987613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00719-15
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