The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support β-Barrel Pore Insertion

The majority of cholesterol-dependent cytolysins (CDCs) utilize cholesterol as a membrane receptor, whereas a small number are restricted to the GPI-anchored protein CD59 for initial membrane recognition. Two cholesterol-binding CDCs, perfringolysin O (PFO) and streptolysin O (SLO), were found to ex...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Farrand, Allison J., Hotze, Eileen M., Sato, Takehiro K., Wade, Kristin R., Wimley, William C., Johnson, Arthur E., Tweten, Rodney K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505022/
https://ncbi.nlm.nih.gov/pubmed/26032415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656769
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