IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle

Genetic data suggest that IL-6 trans-signaling may have a pathogenic role in the lung; however, the effects of IL-6 trans-signaling on lung effector cells have not been investigated. In this study, human airway smooth muscle (HASM) cells were treated with IL-6 (classical) or IL-6+sIL6R (trans-signal...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Robinson, Mac B., Deshpande, Deepak A., Chou, Jeffery, Cui, Wei, Smith, Shelly, Langefeld, Carl, Hastie, Annette T., Bleecker, Eugene R., Hawkins, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504976/
https://ncbi.nlm.nih.gov/pubmed/26001777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00288.2014
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