Reduced vascular responses to soluble guanylyl cyclase but increased sensitivity to sildenafil in female rats with type 2 diabetes

Impaired nitric oxide (NO), soluble guanylyl cyclase (sGC), and cyclic guanosine monophosphate (cGMP) signaling (NO-sGC-cGMP) has been implicated in the pathogenesis of diabetic vascular dysfunction. Efforts to directly target this signaling have led to the development of sGC agonists that activate...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Am J Physiol Heart Circ Physiol
Huvudupphovsmän: Goulopoulou, Styliani, Hannan, Johanna L., Matsumoto, Takayuki, Ogbi, Safia, Ergul, Adviye, Webb, R. Clinton
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2015
Ämnen:
Vascular Biology and Microcirculation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504970/
https://ncbi.nlm.nih.gov/pubmed/25957216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00079.2015
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk