Sustained release nitrite therapy results in myocardial protection in a porcine model of metabolic syndrome with peripheral vascular disease

Metabolic syndrome (MetS) reduces endothelial nitric oxide (NO) bioavailability and exacerbates vascular dysfunction in patients with preexisting vascular diseases. Nitrite, a storage form of NO, can mediate vascular function during pathological conditions when endogenous NO is reduced. The aims of...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Bradley, Jessica M., Islam, Kazi N., Polhemus, David J., Donnarumma, Erminia, Brewster, Luke P., Tao, Ya-Xiong, Goodchild, Traci T., Lefer, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
Schlagworte:
Vascular Biology and Microcirculation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504965/
https://ncbi.nlm.nih.gov/pubmed/25957218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00163.2015
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