The mTORC1 inhibitor everolimus has antitumor activity in vitro and produces tumor responses in patients with relapsed T-cell lymphoma

Everolimus is an oral agent that targets the mammalian target of rapamycin (mTOR) pathway. This study investigated mTOR pathway activation in T-cell lymphoma (TCL) cell lines and assessed antitumor activity in patients with relapsed/refractory TCL in a phase 2 trial. The mTOR pathway was activated i...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Witzig, Thomas E., Reeder, Craig, Han, Jing Jing, LaPlant, Betsy, Stenson, Mary, Tun, Han W., Macon, William, Ansell, Stephen M., Habermann, Thomas M., Inwards, David J., Micallef, Ivana N., Johnston, Patrick B., Porrata, Luis F., Colgan, Joseph P., Markovic, Svetomir, Nowakowski, Grzegorz S., Gupta, Mamta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504947/
https://ncbi.nlm.nih.gov/pubmed/25921059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-629543
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