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Defective TFH cell function and increased TFR cells contribute to defective antibody production in aging
Defective antibody production in aging is broadly attributed to immunosenescence. However, the precise immunological mechanisms remain unclear. Here we demonstrate an increase in the ratio of inhibitory T follicular regulatory (Tfr) cells to stimulatory T follicular helper (Tfh) cells in aged mice....
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| Publicado en: | Cell Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4504745/ https://ncbi.nlm.nih.gov/pubmed/26146074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.015 |
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