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Defective TFH cell function and increased TFR cells contribute to defective antibody production in aging

Defective antibody production in aging is broadly attributed to immunosenescence. However, the precise immunological mechanisms remain unclear. Here we demonstrate an increase in the ratio of inhibitory T follicular regulatory (Tfr) cells to stimulatory T follicular helper (Tfh) cells in aged mice....

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Sage, Peter T., Tan, Catherine L., Freeman, Gordon J., Haigis, Marcia, Sharpe, Arlene H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504745/
https://ncbi.nlm.nih.gov/pubmed/26146074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.015
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