Defective TFH cell function and increased TFR cells contribute to defective antibody production in aging

Defective antibody production in aging is broadly attributed to immunosenescence. However, the precise immunological mechanisms remain unclear. Here we demonstrate an increase in the ratio of inhibitory T follicular regulatory (Tfr) cells to stimulatory T follicular helper (Tfh) cells in aged mice....

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Sage, Peter T., Tan, Catherine L., Freeman, Gordon J., Haigis, Marcia, Sharpe, Arlene H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504745/
https://ncbi.nlm.nih.gov/pubmed/26146074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.015
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