Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer

We report here on experimental and theoretical efforts to determine how best to combine drugs that inhibit HER2 and AKT in HER2(+) breast cancers. We accomplished this by measuring cellular and molecular responses to lapatinib and the AKT inhibitors (AKT(i)) GSK690693 and GSK2141795 in a panel of 22...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Korkola, James E., Collisson, Eric A., Heiser, Laura, Oates, Chris, Bayani, Nora, Itani, Sleiman, Esch, Amanda, Thompson, Wallace, Griffith, Obi L., Wang, Nicholas J., Kuo, Wen-Lin, Cooper, Brian, Billig, Jessica, Ziyad, Safiyyah, Hung, Jenny L., Jakkula, Lakshmi, Feiler, Heidi, Lu, Yiling, Mills, Gordon B., Spellman, Paul T., Tomlin, Claire, Mukherjee, Sach, Gray, Joe W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504492/
https://ncbi.nlm.nih.gov/pubmed/26181325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133219
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