The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model

Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, occasionally causes severe neurological symptoms. We identified P-selectin glycoprotein ligand-1 (PSGL-1) as an EV71 receptor and found that an amino acid residue 145 in the capsid protein VP1 (VP1-145) defined PSGL-1-b...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Kataoka, Chikako, Suzuki, Tadaki, Kotani, Osamu, Iwata-Yoshikawa, Naoko, Nagata, Noriyo, Ami, Yasushi, Wakita, Takaji, Nishimura, Yorihiro, Shimizu, Hiroyuki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504482/
https://ncbi.nlm.nih.gov/pubmed/26181772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005033
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