Epratuzumab inhibits the production of the proinflammatory cytokines IL-6 and TNF-α, but not the regulatory cytokine IL-10, by B cells from healthy donors and SLE patients

INTRODUCTION: Cytokines produced by B cells are believed to play important roles in autoimmune diseases. CD22 targeting by epratuzumab has been demonstrated to inhibit phosphorylation of B cell receptor (BCR) downstream signaling in B cells. It has been shown that other sialoadhesin molecules relate...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Fleischer, Vanessa, Sieber, Julia, Fleischer, Sarah J., Shock, Anthony, Heine, Guido, Daridon, Capucine, Dörner, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504352/
https://ncbi.nlm.nih.gov/pubmed/26183319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0686-2
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