Enhancement of the TCRζ Expression, Polyclonal Expansion, and Activation of T Cells from Patients with Acute Myeloid Leukemia After IL-2, IL-7, and IL-12 Induction

Defective T cell receptor (TCR) signaling resulting in lower T cell function plays a crucial role in the pathogenesis of T cell immunodeficiency in leukemia. Previous studies have indicated that lower TCRζ levels are a common characteristic of patients with leukemia, and upregulating TCRζ could part...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:DNA Cell Biol
Hauptverfasser: Shi, Li, Chen, Shaohua, Zha, Xianfeng, Xu, Yan, Xu, Ling, Yang, Lijian, Lu, Yuhong, Zhu, Kanger, Li, Yangqiu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2015
Schlagworte:
Molecular Mechanisms of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504257/
https://ncbi.nlm.nih.gov/pubmed/25757160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2015.2810
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