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Constitutively Active Foxo3 in Oocytes Preserves Ovarian Reserve in Mice

During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We fin...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Pelosi, Emanuele, Omari, Shakib, Michel, Marc, Ding, Jun, Amano, Tomokazu, Forabosco, Antonino, Schlessinger, David, Ottolenghi, Chris
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504230/
https://ncbi.nlm.nih.gov/pubmed/23673628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2861
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