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Constitutively Active Foxo3 in Oocytes Preserves Ovarian Reserve in Mice

During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We fin...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pelosi, Emanuele, Omari, Shakib, Michel, Marc, Ding, Jun, Amano, Tomokazu, Forabosco, Antonino, Schlessinger, David, Ottolenghi, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504230/
https://ncbi.nlm.nih.gov/pubmed/23673628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2861
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