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Constitutively Active Foxo3 in Oocytes Preserves Ovarian Reserve in Mice
During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We fin...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4504230/ https://ncbi.nlm.nih.gov/pubmed/23673628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2861 |
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