Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer

BACKGROUND: Fatty acid synthase (FASN) is crucial to de novo long-chain fatty acid synthesis, needed to meet cancer cells’ increased demands for membrane, energy, and protein production. METHODS: We investigated FASN overexpression as a therapeutic and chemosensitization target in ovarian cancer tis...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Bauerschlag, Dirk O, Maass, Nicolai, Leonhardt, Peter, Verburg, Frederik A, Pecks, Ulrich, Zeppernick, Felix, Morgenroth, Agnieszka, Mottaghy, Felix M, Tolba, Rene, Meinhold-Heerlein, Ivo, Bräutigam, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504229/
https://ncbi.nlm.nih.gov/pubmed/25947066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0511-3
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