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The Remarkable Stability of Chimeric, Sialic Acid-derived α/δ-Peptides in Human Blood Plasma

Peptides are labile toward proteolytic enzymes, and structural modifications are often required to prolong their metabolic half-life and increase resistance. One modification is the incorporation of non-α-amino acids into the peptide to deter recognition by hydrolytic enzymes. We previously reported...

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Dettagli Bibliografici
Pubblicato in:Chem Biol Drug Des
Autori principali: Saludes, Jonel P., Natarajan, Arutselvan, DeNardo, Sally J., Gervay-Hague, Jacquelyn
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504198/
https://ncbi.nlm.nih.gov/pubmed/20486931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.00954.x
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