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Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors

A modular replacement approach to the synthesis of sulfonucleotide analogs prepared from condensation of nucleoside aldehydes with bis phosphonate Horner-Wadsworth-Emmons reagents is disclosed. These analogs were shown to be inhibitors of Neisseria meningitidis CSS (NmCSS), which is a key enzyme in...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Org Biomol Chem
Egile Nagusiak: Wong, Jessica H., Sahni, Urvashi, Li, Yanhong, Chen, Xi, Gervay-Hague, Jacquelyn
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505548/
https://ncbi.nlm.nih.gov/pubmed/19081938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b819155g
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