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Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors
A modular replacement approach to the synthesis of sulfonucleotide analogs prepared from condensation of nucleoside aldehydes with bis phosphonate Horner-Wadsworth-Emmons reagents is disclosed. These analogs were shown to be inhibitors of Neisseria meningitidis CSS (NmCSS), which is a key enzyme in...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505548/ https://ncbi.nlm.nih.gov/pubmed/19081938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b819155g |
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