Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells

The mevalonate pathway provides metabolites for post-translational modifications such as farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently occurring regulatory processes can induce an aberrant stimulation of DNA methyltransferase (DNMT1) as well as changes...

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Опубликовано в: :Cancer Genet
Главные авторы: Karlic, Heidrun, Thaler, Roman, Gerner, Christopher, Grunt, Thomas, Proestling, Katharina, Haider, Florian, Varga, Franz
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2015
Предметы:
Contributions to Progress and Promise of Epigenetics for Diagnosis and Therapy in Cancer
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503872/
https://ncbi.nlm.nih.gov/pubmed/25978957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergen.2015.03.008
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