Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells

The mevalonate pathway provides metabolites for post-translational modifications such as farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently occurring regulatory processes can induce an aberrant stimulation of DNA methyltransferase (DNMT1) as well as changes...

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Detalhes bibliográficos
Publicado no:Cancer Genet
Main Authors: Karlic, Heidrun, Thaler, Roman, Gerner, Christopher, Grunt, Thomas, Proestling, Katharina, Haider, Florian, Varga, Franz
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Contributions to Progress and Promise of Epigenetics for Diagnosis and Therapy in Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503872/
https://ncbi.nlm.nih.gov/pubmed/25978957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergen.2015.03.008
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