Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets

INTRODUCTION: ColoPulse tablets are an innovative development in the field of oral dosage forms characterized by a distal ileum and colon-specific release. Previous studies in humans showed release in the ileo-colonic region, but the relationship between gastrointestinal pH and release was not exper...

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Publié dans:PLoS One
Auteurs principaux: Maurer, Jacoba M., Schellekens, Reinout C. A., van Rieke, Hèlen M., Wanke, Christoph, Iordanov, Ventzeslav, Stellaard, Frans, Wutzke, Klaus D., Dijkstra, Gerard, van der Zee, Margot, Woerdenbag, Herman J., Frijlink, Henderik W., Kosterink, Jos G. W.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503763/
https://ncbi.nlm.nih.gov/pubmed/26177019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129076
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